As with most species of Cladosporium, C. sphaerospermum is common worldwide. This species can be isolated from plants, soil, food, paint, textiles, insulation, floor dust, mattress dust, humidifiers and from humans and other animals. Spores of this species are difficult to distinguish from those of C. cladosporioides microscopically, but DNA analyses easily distinguish them. C. sphaerospermum is one of the most commonly isolated indoor air fungi. This species is allergenic and has caused documented bronchial lesions and subcutaneous skin infections.
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